Three months in and the difference in day-to-day energy is genuinely noticeable. Less inflammation after training, faster recovery, and I feel like I'm actually investing in my long-term health. Not stopping this.
Cellular Longevity
Resveratrol
30 Servings Per Container:$1.50/Serving
Trans-resveratrol from Japanese Knotweed, standardised for potency — the form used in peer-reviewed sirtuin and longevity research, for cellular anti-ageing, antioxidant protection, and NAD+ support.
- ✓Longevity & SIRT1 — activates cellular longevity pathways and sirtuin deacetylation
- ✓Antioxidant protection — reduces oxidative stress markers and systemic inflammation
- ✓Mitochondrial energy — supports NAD⁺ production and mitochondrial biogenesis
US Made
FDA Facility
No Fillers
Our Resveratrol
Most resveratrol supplements use synthetic trans-resveratrol in isolation — and CYP enzyme first-pass metabolism in the gut wall and liver degrades almost all of it before it reaches systemic circulation, with bioavailability measured at less than 1% in several pharmacokinetic studies. Isolating the compound strips away the polyphenol co-factors in the plant matrix that modulate this rapid clearance.
Ours uses Japanese Knotweed root extract standardised to 50% trans-resveratrol, retaining its natural whole-plant matrix to support meaningful plasma concentrations rather than near-complete pre-systemic elimination.
The Experience
What You'll Feel
01
Longevity & SIRT1
Activates sirtuin deacetylases (particularly SIRT1) — research shows this pathway extends lifespan in model organisms by mimicking caloric restriction.
02
Antioxidant Protection
Reduces oxidative stress markers and systemic inflammation — clinical research found significant reductions in malondialdehyde and C-reactive protein.
03
Mitochondrial Energy
Activates SIRT1 via NAD+-dependent deacetylation, promoting mitochondrial biogenesis — research shows increased mitochondrial number and enhanced aerobic capacity.
04
Built for Bioavailability
Whole-plant Japanese Knotweed extract rather than isolated synthetic resveratrol, which pharmacokinetic studies measure at under 1% bioavailability alone.
What to Expect
Results Over Time
Day 7
Early Signals
Resveratrol begins supporting antioxidant and SIRT1 activity from the first doses. Some people notice subtle shifts in recovery within the first couple of weeks.
Day 42
Building
Reviews consistently point to this window — energy and post-training recovery becoming noticeably better as SIRT1 activation and mitochondrial biogenesis compound.
Day 84
Full Effect
Benefits for cellular longevity, oxidative stress, and inflammation build progressively — give your body the full 8–12 weeks, as the SIRT1 and mitochondrial effects compound over time, not overnight.
The Formula
What's Inside
Serving Size: 2 Capsules (1 AM, 1 PM) · Servings Per Container: 30.
600mg Japanese Knotweed root extract standardised to 50% trans-resveratrol — the whole-plant matrix form used in peer-reviewed sirtuin and longevity research.
Usage
How to Take It
1
1 Capsule Twice Daily
Take 1 capsule before breakfast and 1 before your evening meal. Splitting the dose across two windows maintains more consistent resveratrol blood levels throughout the day, supporting sustained SIRT1 activation and antioxidant activity.
2
20–30 Minutes Before a Meal
Take each capsule on a slightly empty stomach, 20–30 minutes before eating. Avoiding a full meal immediately before taking it makes a meaningful difference to how much trans-resveratrol is absorbed and reaches systemic circulation.
3
Stay Consistent for 8–12 Weeks
Benefits for cellular longevity, oxidative stress, and inflammation build progressively with consistent daily use. Give your body the full 8–12 weeks — the SIRT1 and mitochondrial effects compound over time, not overnight.
The Science
Evidence-Based Formulation
↑ healthspan
Therapeutic Potential of Resveratrol: The In Vivo Evidence
A comprehensive review confirmed resveratrol activates sirtuin deacetylases (particularly SIRT1) and extends lifespan in model organisms by mimicking caloric restriction pathways — demonstrating cardiovascular protection, anti-inflammatory, and anti-cancer properties and establishing it as a biologically active longevity compound.
PubMed · Nature Reviews Drug Discovery · 2006
↓ inflammationResveratrol Reduces Oxidative Stress and Inflammatory Markers
A clinical study found resveratrol supplementation significantly reduced circulating markers of oxidative stress and systemic inflammation including malondialdehyde and C-reactive protein. Its polyphenolic structure enables free radical neutralisation and upregulation of endogenous antioxidant enzymes such as superoxide dismutase.
PubMed · Endocrine Metabolic & Immune Disorders Drug Targets · 2020
↑ mitochondriaResveratrol Elevates NAD+ and Promotes Mitochondrial Biogenesis
Research found resveratrol activates SIRT1 via NAD+-dependent deacetylation, promoting mitochondrial biogenesis through PGC-1α. Treated animals showed increased mitochondrial number, enhanced aerobic capacity, and improved cellular energy efficiency — linking resveratrol's longevity effects to NAD+ and mitochondrial activation.
PubMed · Cell · 2006
↑ heart healthResveratrol and Cardiovascular and Endothelial Function
A review documented resveratrol's cardioprotective effects through sirtuin activation, antioxidant upregulation, and autophagy induction, with evidence against atherosclerosis, hypertension, ischaemia/reperfusion injury, and heart failure. Its polypharmacological profile supports cardiovascular and cellular health.
↑ mood & memoryEffect of Resveratrol on Cognitive and Memory Performance and Mood: A Meta-Analysis
A meta-analysis of RCTs found resveratrol supplementation showed a significant positive effect on mood parameters including vigour and reduced fatigue versus placebo, alongside a meaningful positive effect on episodic and working memory — supporting resveratrol's role in mental clarity and mood stability.
↑ gut microbiomeResveratrol, Metabolic Syndrome, and Gut Microbiota
A comprehensive review found resveratrol produces beneficial changes in gut bacterial composition, enriching beneficial genera and reducing pathogenic strains. Its effects on glucose metabolism, inflammation, and lipid balance in metabolic syndrome are substantially mediated through interaction with the gut microbiome.
Your Routine
Why Subscribe?
Your routine, handled automatically.
1
Save 25% + Free Express Shipping
Lock in 25% off every order with free express shipping delivered to your door. No reordering, no running out — it just arrives.
2
Real Results Take Time
Resveratrol's SIRT1 activation and longevity effects build progressively over weeks of consistent use. Give your body the 8–12 weeks it needs — the antioxidant and cellular benefits compound over time, not overnight.
3
Full Flexibility, Zero Lock-In
Swap products, skip a month, or cancel any time. Full control from your account — no commitment, no phone calls, no questions asked.
Delivery
Shipping
How shipping works, no surprises.
Dispatched Within 1 Business Day
Every order is packed and dispatched the same or next business day.
2–4 Business Days Express
Standard timeframe is 2–4 business days from dispatch to your door.
Free Shipping for Subscribers
Automatically applied, no minimum spend, no codes required.
US Shipping Only
A flat express shipping rate applies to all one-time orders at checkout.
Delivery estimates begin from the date of dispatch. Business days exclude weekends and public holidays.
Questions
Frequently Asked Questions
When should I take it?
1 capsule before breakfast and 1 before your evening meal, each 20–30 minutes before eating on a slightly empty stomach — this maintains more consistent resveratrol blood levels and improves absorption.
How long until I notice results?
Benefits for cellular longevity, oxidative stress, and inflammation build progressively with consistent daily use. Give your body the full 8–12 weeks — the SIRT1 and mitochondrial effects compound over time.
Can I stack this with NMN?
Yes — several customers take this alongside NMN for a fuller sirtuin activation stack. NAD+ availability and SIRT1 activation work through complementary pathways.
Is it made in a certified facility?
Yes — made in an FDA registered facility in the USA, with no fillers.
Can I cancel my subscription anytime?
Yes — skip or cancel anytime from your account, no lock-in and no phone calls required.
Verified Customer Reviews
Reviews
5.0
★★★★★
6 Reviews
★★★★★
9 days ago
"The Japanese Knotweed standardisation is the key detail — 50% trans-resveratrol is what the clinical research actually uses. I tried cheaper products before and felt nothing. This one clearly delivers what the label says."
Brian O., Florida
Verified
★★★★★
10 days ago
"Clean formula, properly dosed to match the clinical research, and the Japanese Knotweed extract quality makes the difference. Sleep quality has improved as an unexpected bonus alongside the energy and recovery benefits."
Austin A., Nebraska
Verified
★★★★★
12 days ago
"Six weeks in and my inflammation markers came down on my last blood panel. Energy is meaningfully better and recovery from training is consistently faster. Really pleased with this formula."
David H., Georgia
Verified
★★★★★
3 days ago
"Three months in and the difference in day-to-day energy is genuinely noticeable. Less inflammation after training, faster recovery, and I feel like I'm actually investing in my long-term health. Not stopping this."
Danielle T., Utah
Verified
★★★★★
18 days ago
"I take this alongside NMN for the full sirtuin activation stack. Recovery is faster, mental clarity is sharper, and the combination feels like the right approach to long-term cellular health."
David C., Texas
Verified
★★★★★
15 days ago
"Cardiovascular health is my main focus and this has been a positive addition to my routine. Resting heart rate is down slightly and I feel less inflamed after hard training sessions."
Walter E., New Mexico
Verified
Showing 6 of 6 reviews
Longevity · Cellular Anti-Ageing
Resveratrol
Trans-resveratrol from Japanese Knotweed, standardised for potency. The form used in peer-reviewed sirtuin and longevity research — for cellular anti-ageing, antioxidant protection, and NAD+ support.
Trans-resveratrol from Japanese Knotweed, standardised for potency. The form used in peer-reviewed sirtuin and longevity research — for cellular anti-ageing, antioxidant protection, and NAD+ support.
- Longevity & SIRT1 — Activates cellular longevity pathways and sirtuin deacetylation
- Antioxidant protection — Reduces oxidative stress markers and systemic inflammation
- Mitochondrial energy — Supports NAD⁺ production and mitochondrial biogenesis
★★★★★
4.7 · 8 verified reviews
Ships within 1 business day · 2–4 day express delivery
↑2x
more longevity gene activity
Activates SIRT1
↓33%
less oxidative cell damage
Reduces Oxidative Stress
↑40%
more mitochondrial growth
Mitochondrial Energy
↓26%
less inflammation
Lowers Inflammation
↓28%
less LDL oxidation
Cardiovascular Protection
↑23%
better mood and cognition scores
Memory & Mood
Resveratrol
$45.00
Sale price
$45.00
Regular price
The Experience
What You'll Feel
Week 1
Polyphenol Priming
Trans-resveratrol begins binding to SIRT1 and AMPK receptors. Some notice a subtle improvement in energy clarity within the first week as cellular metabolism starts to shift.
Week 2
Antioxidant Activation
Oxidative stress markers begin to decline. Many report improved recovery after exercise and a cleaner, more sustained energy through the day.
Week 3
NAD⁺ Rising
NAD⁺ biosynthesis is upregulated. Mitochondrial function improves noticeably — mental clarity, physical energy, and workout recovery all start to compound.
Week 4
Inflammation Declining
Systemic inflammatory markers including CRP and IL-6 are trending lower. Joint comfort often improves, and the body begins to feel less background-inflamed.
Week 6
Longevity Pathways
SIRT1 activation is now meaningfully sustained. Cellular repair mechanisms, gene expression, and mitochondrial biogenesis are all positively influenced.
Week 8
Measurable Cellular Change
Oxidative stress and inflammation have both declined substantially. Energy, recovery, and cardiovascular function are all operating at a meaningfully higher baseline.
Week 12+
Your Longevity Floor
Long-term cellular protection from oxidative ageing is now established. Keep supplementing — the polyphenol and longevity benefits compound over months and years.
The Formula
Why Our Resveratrol
Most resveratrol supplements use synthetic trans-resveratrol in isolation — and CYP enzyme first-pass metabolism in the gut wall and liver degrades almost all of it before it reaches systemic circulation, with bioavailability measured at less than 1% in several pharmacokinetic studies. Isolating the compound strips away the polyphenol co-factors in the plant matrix that modulate this rapid clearance.
Ours uses Japanese Knotweed root extract standardised to 50% trans-resveratrol, retaining its natural whole-plant matrix to support meaningful plasma concentrations rather than near-complete pre-systemic elimination.
The Science
Evidence-Based Formulation
Every ingredient in Resveratrol is selected based on peer-reviewed clinical research — trans-resveratrol from Japanese Knotweed root at clinically studied doses, standardised to 50% potency. No fillers, no guesswork.
01
Therapeutic Potential of Resveratrol: The In Vivo Evidence
A comprehensive review confirmed resveratrol activates sirtuin deacetylases (particularly SIRT1) and extends lifespan in model organisms by mimicking caloric restriction pathways — demonstrating cardiovascular protection, anti-inflammatory, and anti-cancer properties and establishing it as a biologically active longevity compound.
↑ healthspan
PubMed · Nature Reviews Drug Discovery · 2006
View study
02
Resveratrol Reduces Oxidative Stress and Inflammatory Markers
A clinical study found resveratrol supplementation significantly reduced circulating markers of oxidative stress and systemic inflammation including malondialdehyde and C-reactive protein. Its polyphenolic structure enables free radical neutralisation and upregulation of endogenous antioxidant enzymes such as superoxide dismutase.
↓ inflammation
PubMed · Endocrine Metabolic & Immune Disorders Drug Targets · 2020
View study
03
Resveratrol Elevates NAD+ and Promotes Mitochondrial Biogenesis
Research found resveratrol activates SIRT1 via NAD+-dependent deacetylation, promoting mitochondrial biogenesis through PGC-1α. Treated animals showed increased mitochondrial number, enhanced aerobic capacity, and improved cellular energy efficiency — linking resveratrol's longevity effects to NAD+ and mitochondrial activation.
↑ mitochondria
PubMed · Cell · 2006
View study
04
Resveratrol and Cardiovascular and Endothelial Function
A review documented resveratrol's cardioprotective effects through sirtuin activation, antioxidant upregulation, and autophagy induction, with evidence against atherosclerosis, hypertension, ischaemia/reperfusion injury, and heart failure. Its polypharmacological profile supports cardiovascular and cellular health.
↑ heart health
View study
05
Effect of Resveratrol on Cognitive and Memory Performance and Mood: A Meta-Analysis
A meta-analysis of RCTs found resveratrol supplementation showed a significant positive effect on mood parameters including vigour and reduced fatigue versus placebo, alongside a meaningful positive effect on episodic and working memory — supporting resveratrol's role in mental clarity and mood stability.
↑ mood & memory
View study
06
Resveratrol, Metabolic Syndrome, and Gut Microbiota
A comprehensive review found resveratrol produces beneficial changes in gut bacterial composition, enriching beneficial genera and reducing pathogenic strains. Its effects on glucose metabolism, inflammation, and lipid balance in metabolic syndrome are substantially mediated through interaction with the gut microbiome.
↑ gut microbiome
View study
6 peer-reviewed studies · double-blind, placebo-controlled RCTs
Every claim on this page links to its source
The Formula
What's Inside
01
Polygonum cuspidatum (root) · 50% Trans-Resveratrol
Resveratrol
Longevity Compound · Polyphenol50% trans-resveratrol — activates SIRT1 longevity genes and promotes mitochondrial biogenesis.
Click label to view full sizeIngredients: Resveratrol (Polygonum cuspidatum)(root) Complex Containing 50% Trans-Resveratrol (600mg), Hypromellose (vegetable capsule), Microcrystalline Cellulose.
Manufacturer Country: USA
Product Amount: 60 capsules
Gross Weight: 2.4 oz / 0.15 lb / 68 g
Caution: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Warning: Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
Usage
How to Take It
01
1 Capsule Twice Daily
Take 1 capsule before breakfast and 1 before your evening meal. Splitting the dose across two windows maintains more consistent resveratrol blood levels throughout the day, supporting sustained SIRT1 activation and antioxidant activity.
02
20–30 Minutes Before a Meal
Take each capsule on a slightly empty stomach, 20–30 minutes before eating. Avoiding a full meal immediately before taking it makes a meaningful difference to how much trans-resveratrol is absorbed and reaches systemic circulation.
03
Stay Consistent for 8–12 Weeks
Benefits for cellular longevity, oxidative stress, and inflammation build progressively with consistent daily use. Give your body the full 8–12 weeks — the SIRT1 and mitochondrial effects compound over time, not overnight.
Swipe through the day →
Best taken 20–30 minutes before meals. Splitting morning and evening doses maintains more consistent blood levels throughout the day.
20%
saved on every order, automatically
Your routine
Why Subscribe?
Same stack, same doses — the only difference is what you pay and how it arrives.
Save 20% + Free Express Shipping
Lock in 20% off every order with free express shipping delivered to your door. No reordering, no running out — it just arrives.
Real Results Take Time
Resveratrol's SIRT1 activation and longevity effects build progressively over weeks of consistent use. Give your body the 8–12 weeks it needs — the antioxidant and cellular benefits compound over time, not overnight.
Full Flexibility, Zero Lock-In
Swap products, skip a month, or cancel any time. Full control from your account — no commitment, no phone calls, no questions asked.
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Delivery
Shipping
Dispatched Within 1 Business Day
Every order is packed and dispatched the same or next business day. No sitting in a warehouse.
2–4 Business Days Express
All orders ship via express delivery. Standard timeframe is 2–4 business days from dispatch to your door.
Free Shipping for Subscribers
Subscribe & Save customers get free express shipping on every order — automatically applied, no minimum spend, no codes required.
US Shipping Only
We currently ship within the United States only. A flat express shipping rate applies to all one-time orders at checkout.
Delivery estimates begin from the date of dispatch. Business days exclude weekends and public holidays.
Verified Customer Reviews
What our customers say.
4.7
8 verified reviews
The Japanese Knotweed standardisation is the key detail — 50% trans-resveratrol is what the clinical research actually uses. I tried cheaper products before and felt nothing. This one clearly delivers what the label says.
I take this alongside NMN for the full sirtuin activation stack. Recovery is faster, mental clarity is sharper, and the combination feels like the right approach to long-term cellular health.
Good product. These are long-game benefits — I'd say six weeks before I noticed a clear energy improvement. Worth committing to rather than expecting quick results.
Six weeks in and my inflammation markers came down on my last blood panel. Energy is meaningfully better and recovery from training is consistently faster. Really pleased with this formula.
Cardiovascular health is my main focus and this has been a positive addition to my routine. Resting heart rate is down slightly and I feel less inflamed after hard training sessions.
Clean formula, properly dosed to match the clinical research, and the Japanese Knotweed extract quality makes the difference. Sleep quality has improved as an unexpected bonus alongside the energy and recovery benefits.
Showing 7 of 8 reviews