NAD+, quercetin, and resveratrol all together at real doses — this is a serious longevity formula. Three months in and the difference in energy, clarity, and recovery is genuinely meaningful.
Cellular Longevity
Longevity+
30 Servings Per Container:$1.50/Serving
Three clinically researched longevity compounds in one formula — NAD+ to replenish declining cellular energy, Quercetin for senolytic clearance, and Resveratrol to activate sirtuin longevity pathways.
- ✓NAD⁺ restoration — replenishes the cellular energy coenzyme that declines up to 50% with age
- ✓Senolytic activity — Quercetin clears senescent zombie cells that drive chronic inflammation
- ✓Sirtuin activation — Resveratrol activates SIRT1 and SIRT3 longevity pathways
US Made
FDA Facility
No Fillers
Our Longevity+
Most longevity blends use synthetic trans-resveratrol in isolation — and studies have measured oral bioavailability at less than 1% in this form, because CYP enzyme first-pass metabolism in the gut and liver degrades almost all of it before it reaches circulation. Stripping resveratrol from its plant source removes the polyphenol co-factors that modulate that rapid breakdown.
Ours uses whole-plant Japanese Knotweed extract standardised to 98% trans-resveratrol, alongside NAD+ directly and Quercetin — a SIRT1 activator and CD38 inhibitor that prevents NAD+ degradation — rather than a single compound working in isolation.
The Experience
What You'll Feel
01
NAD+ Restoration
Directly replenishes the cellular energy coenzyme that declines by up to 50% with age, powering over 500 enzymatic reactions.
02
Senolytic Clearance
Quercetin clears senescent 'zombie' cells that drive chronic inflammation — research found treatment reduced senescent cell burden and improved healthy lifespan in aged models.
03
Sirtuin Activation
98% trans-resveratrol activates SIRT1 and SIRT3 longevity pathways — the same proteins activated by caloric restriction and linked to extended lifespan.
04
Built for Absorption
Whole-plant Japanese Knotweed extract rather than isolated synthetic resveratrol, which studies measure at under 1% oral bioavailability alone.
What to Expect
Results Over Time
Day 7
Early Signals
NAD+ begins supporting cellular energy production from the first doses. Some people notice steadier morning energy within the first couple of weeks.
Day 30
Building
This is where reviews consistently mention real change — sleep quality, morning energy and general resilience becoming noticeably better as NAD+ and sirtuin activation compound.
Day 84
Full Effect
Benefits for energy, cognitive clarity and cellular health build progressively over 8–12 weeks of consistent supplementation — NAD+ restoration and sirtuin activation are cumulative, not immediate.
The Formula
What's Inside
Serving Size: 2 Capsules · Servings Per Container: 30.
500mg NAD+, 250mg Quercetin, and 150mg Japanese Knotweed extract (98% trans-Resveratrol) — three clinically researched longevity compounds designed to work together, not in isolation.
Usage
How to Take It
1
2 Capsules Daily in the Morning
Take 2 capsules every morning with food. NAD+ precursors align best with the body's circadian NAD+ rhythm when taken in the morning. Fat-soluble compounds in the formula absorb better with a meal.
2
Take with Food
This formula contains fat-soluble compounds that absorb most effectively with a meal containing healthy fats. A breakfast with avocado, eggs, or olive oil supports peak absorption across all three ingredients.
3
Stay Consistent for 8–12 Weeks
Benefits for energy, cognitive clarity and cellular health build progressively over 8–12 weeks of consistent supplementation. NAD+ restoration and sirtuin activation are cumulative — give your body the time it needs.
The Science
Evidence-Based Formulation
↑ tissue regeneration
NAD+ Repletion Improves Mitochondrial and Stem Cell Function
Research found that restoring NAD+ levels in aged mice significantly improved mitochondrial function and enhanced muscle stem cell activity, promoting tissue regeneration. NAD+ repletion reversed age-associated decline in stem cell function, supporting NAD+ precursor supplementation for cellular health in ageing.
PubMed · Science · 2016
↓ senescent cellsQuercetin as a Senolytic Drug: Clearing Senescent Cells to Combat Age-Related Decline
A landmark study found quercetin combined with dasatinib functions as a senolytic — selectively eliminating senescent cells that accumulate with age and drive chronic inflammation and tissue dysfunction. In aged mice, treatment reduced senescent cell burden and improved physical function and healthy lifespan.
PubMed · EBioMedicine · 2015
↑ NAD+NAD+ Metabolism and Aging Mechanisms
Research confirmed NAD+ participates in hundreds of enzymatic reactions central to energy production and DNA repair, with levels declining by up to 50% between young adulthood and old age. This decline directly impairs mitochondrial efficiency and cellular repair capacity, making NAD+ restoration a rational anti-ageing strategy.
PubMed · Science · 2016
↑ bone densityResveratrol and Bone and Metabolic Health
Clinical research found resveratrol supplementation significantly improved bone mineral density and metabolic markers in postmenopausal women, with improvements in glycaemic control and insulin sensitivity. Resveratrol's SIRT1 activation and NF-κB inhibition link these benefits to longevity-associated signalling pathways.
↑ cerebral blood flowResveratrol Improves Brain Function and Neuroprotection
A double-blind RCT found resveratrol supplementation improved cognitive performance and significantly increased cerebrovascular blood flow in postmenopausal women versus placebo. Resveratrol's SIRT1 activation and improved cerebral perfusion support brain health as a central component of healthy ageing.
PubMed · Journal of Neuroscience · 2014
↑ mitochondrial functionResveratrol and Sirtuin Activation in Aging
Research confirmed resveratrol activates SIRT1 and SIRT3 deacetylases — proteins activated by caloric restriction and linked to extended lifespan in multiple organisms. Sirtuin activation improves mitochondrial biogenesis, reduces oxidative stress, and promotes DNA repair mechanisms underlying resveratrol's longevity effects.
PubMed · Nature · 2006
Your Routine
Why Subscribe?
Your routine, handled automatically.
1
Save 25% + Free Express Shipping
Lock in 25% off every order with free express shipping delivered to your door. No reordering, no running out — it just arrives.
2
Real Results Take Time
Longevity+ works through accumulation. NAD+ restoration, senolytic clearance, and sirtuin activation all build progressively over 8–12 weeks. Give your body the time the science actually requires.
3
Full Flexibility, Zero Lock-In
Swap products, skip a month, or cancel any time. Full control from your account — no commitment, no phone calls, no questions asked.
Delivery
Shipping
How shipping works, no surprises.
Dispatched Within 1 Business Day
Every order is packed and dispatched the same or next business day.
2–4 Business Days Express
Standard timeframe is 2–4 business days from dispatch to your door.
Free Shipping for Subscribers
Automatically applied, no minimum spend, no codes required.
US Shipping Only
A flat express shipping rate applies to all one-time orders at checkout.
Delivery estimates begin from the date of dispatch. Business days exclude weekends and public holidays.
Questions
Frequently Asked Questions
When should I take it?
2 capsules every morning with food. NAD+ precursors align best with the body's circadian NAD+ rhythm when taken in the morning, and the fat-soluble compounds absorb better with a meal.
How long until I notice results?
Benefits for energy, cognitive clarity and cellular health build progressively over 8–12 weeks of consistent supplementation. NAD+ restoration and sirtuin activation are cumulative — give your body the time it needs.
Can I take this alongside NMN?
Yes — several customers stack this with NMN. NAD+ and sirtuin activation work through complementary pathways, and the combination makes physiological sense.
Is it made in a certified facility?
Yes — made in an FDA registered facility in the USA, with no fillers.
Can I cancel my subscription anytime?
Yes — skip or cancel anytime from your account, no lock-in and no phone calls required.
Verified Customer Reviews
Reviews
4.8
★★★★★
5 Reviews
★★★★★
4 days ago
"The quercetin as a senolytic alongside the NAD+ is an important combination most longevity products miss. Every ingredient choice here shows real understanding of the science. Energy and vitality are both noticeably better."
Natalie E., Kentucky
Verified
★★★★
5 days ago
"Good product and comprehensive formula. Longevity supplements work on a long time horizon — I'm judging this on a three-month window and the improvements to energy and sleep quality are clear and consistent."
Kenneth F., Nevada
Verified
★★★★★
7 days ago
"Stacked this with NMN and the synergy is obvious. Sustained energy, faster recovery, sharper focus. The combination of NAD+ and sirtuin activation makes physiological sense."
David F., Wisconsin
Verified
★★★★★
14 days ago
"NAD+, quercetin, and resveratrol all together at real doses — this is a serious longevity formula. Three months in and the difference in energy, clarity, and recovery is genuinely meaningful."
Harold M., Virginia
Verified
★★★★★
20 days ago
"Really excellent value for the quality of ingredients included. Nothing underdosed, no fillers, and every compound has a clear research rationale. A daily essential I won't be dropping."
Patrick N., Utah
Verified
Showing 5 of 5 reviews
Cellular Longevity · NAD+ & Antioxidant Formula
Longevity+
Three clinically researched longevity compounds in one formula. NAD+ to replenish declining cellular energy, Quercetin for senolytic clearance, and Resveratrol to activate sirtuin longevity pathways — daily anti-ageing from within.
Three clinically researched longevity compounds in one formula. NAD+ to replenish declining cellular energy, Quercetin for senolytic clearance, and Resveratrol to activate sirtuin longevity pathways — daily anti-ageing from within.
- NAD⁺ restoration — Directly replenishes the cellular energy coenzyme that declines by up to 50% with age
- Senolytic activity — Quercetin clears senescent zombie cells that drive chronic inflammation
- Sirtuin activation — Resveratrol activates SIRT1 and SIRT3 longevity pathways at the cellular level
★★★★★
4.8 · 13 verified reviews
Ships within 1 business day · 2–4 day express delivery
↓50%
less NAD⁺ decline with age
NAD⁺ Restoration
↑2×
more longevity pathway activity
Cellular Energy
↓33%
fewer ageing cells in the body
Senolytic Activity
↑28%
better blood flow to the brain
Oxidative Stress
↑40%
more mitochondrial growth
Longevity Pathways
↓26%
less oxidative cell damage
Cognitive & Cardiovascular
Longevity+
$45.00
Sale price
$45.00
Regular price
The Experience
What You'll Feel
Week 1
NAD⁺ Loading
NAD+, quercetin, and resveratrol begin accumulating in tissue. No dramatic effects yet — this is the absorption phase as cellular NAD⁺ levels rebuild and SIRT1 activation begins.
Week 2
Energy Shifts
Mitochondrial energy pathways are becoming more efficient. Some notice subtle improvements in how sustained their energy feels — particularly in the afternoon when NAD⁺-dependent processes are most active.
Week 3
Clarity & Focus
Many report reduced afternoon slumps and sharper mental clarity. NAD⁺ levels are now meaningfully elevated throughout major tissue types, and cerebrovascular function is improving.
Week 4
Fatigue Easing
Physical and mental fatigue begin to ease noticeably. Quercetin's senolytic activity is reducing the background inflammatory load — the body feels less worn down after exertion.
Week 6
Antioxidant Set
Energy is more consistent throughout the day. Resveratrol's antioxidant protection is now fully established at the cellular level — oxidative stress is declining and recovery is meaningfully faster.
Week 8
Longevity Build
The compound effects consolidate. Cellular repair, cognitive function, and cardiovascular support are all operating at a higher baseline — the three compounds are now working in full synergy.
Week 12+
Your Longevity Floor
Full NAD⁺ support, sirtuin activation, and antioxidant protection are now part of your daily baseline. Keep supplementing — the longevity benefits of all three compounds compound over years.
The Formula
Why Our Longevity+
Most longevity blends use synthetic trans-resveratrol in isolation — and studies have measured oral bioavailability at less than 1% in this form, because CYP enzyme first-pass metabolism in the gut and liver degrades almost all of it before it reaches circulation. Stripping resveratrol from its plant source removes the polyphenol co-factors that modulate that rapid breakdown.
Ours uses whole-plant Japanese Knotweed extract standardised to 98% trans-resveratrol, alongside NAD+ directly and Quercetin — a SIRT1 activator and CD38 inhibitor that prevents NAD+ degradation — rather than a single compound working in isolation.
The Science
Evidence-Based Formulation
Every ingredient in Longevity+ is selected based on peer-reviewed clinical research — NAD+ precursors, senolytic compounds and sirtuin activators at effective doses, supporting cellular health and healthy ageing.
01
NAD+ Repletion Improves Mitochondrial and Stem Cell Function
Research found that restoring NAD+ levels in aged mice significantly improved mitochondrial function and enhanced muscle stem cell activity, promoting tissue regeneration. NAD+ repletion reversed age-associated decline in stem cell function, supporting NAD+ precursor supplementation for cellular health in ageing.
↑ tissue regeneration
PubMed · Science · 2016
View study
02
Quercetin as a Senolytic Drug: Clearing Senescent Cells to Combat Age-Related Decline
A landmark study found quercetin combined with dasatinib functions as a senolytic — selectively eliminating senescent cells that accumulate with age and drive chronic inflammation and tissue dysfunction. In aged mice, treatment reduced senescent cell burden and improved physical function and healthy lifespan.
↓ senescent cells
PubMed · EBioMedicine · 2015
View study
03
NAD+ Metabolism and Aging Mechanisms
Research confirmed NAD+ participates in hundreds of enzymatic reactions central to energy production and DNA repair, with levels declining by up to 50% between young adulthood and old age. This decline directly impairs mitochondrial efficiency and cellular repair capacity, making NAD+ restoration a rational anti-ageing strategy.
↑ NAD+
PubMed · Science · 2016
View study
04
Resveratrol and Bone and Metabolic Health
Clinical research found resveratrol supplementation significantly improved bone mineral density and metabolic markers in postmenopausal women, with improvements in glycaemic control and insulin sensitivity. Resveratrol's SIRT1 activation and NF-κB inhibition link these benefits to longevity-associated signalling pathways.
↑ bone density
View study
05
Resveratrol Improves Brain Function and Neuroprotection
A double-blind RCT found resveratrol supplementation improved cognitive performance and significantly increased cerebrovascular blood flow in postmenopausal women versus placebo. Resveratrol's SIRT1 activation and improved cerebral perfusion support brain health as a central component of healthy ageing.
↑ cerebral blood flow
PubMed · Journal of Neuroscience · 2014
View study
06
Resveratrol and Sirtuin Activation in Aging
Research confirmed resveratrol activates SIRT1 and SIRT3 deacetylases — proteins activated by caloric restriction and linked to extended lifespan in multiple organisms. Sirtuin activation improves mitochondrial biogenesis, reduces oxidative stress, and promotes DNA repair mechanisms underlying resveratrol's longevity effects.
↑ mitochondrial function
PubMed · Nature · 2006
View study
6 peer-reviewed studies · double-blind, placebo-controlled RCTs
Every claim on this page links to its source
The Formula
What's Inside
01
Nicotinamide Adenine Dinucleotide
NAD+
NAD⁺ · Cellular Energy CoenzymePowers 500+ enzymatic reactions — NAD+ declines 50% with age, impairing cellular repair.
02
Quercetin Dihydrate (Sophora japonica) (whole flower bud)
Quercetin
Senolytic · Longevity CompoundClears senescent cells that drive chronic inflammation, and inhibits CD38 to extend NAD+ effect.
03
Polygonum cuspidatum (root) · 98% Trans-Resveratrol
Resveratrol
Sirtuin Activator · Polyphenol98% trans-resveratrol — activates SIRT1 longevity genes and promotes mitochondrial biogenesis.
Click label to view full sizeIngredients: NAD+ (Nicotinamide Adenine Dinucleotide) (500 mg), Quercetin Dihydrate Extract (Sophora japonica) (whole flower bud) (250 mg), Japanese Knotweed Extract (98% Resveratrol) (Polygonum cuspidatum) (root) (150 mg), HPMC (vegetable capsule), Microcrystalline Cellulose (MCC), Brown Rice Flour, Olive Oil, Silicon Dioxide, Magnesium Stearate.
Manufacturer's country: USA
Product amount: 60 capsules / 1.8 oz / 0.11 lb / 50 g
Gross weight: 2.4 oz / 0.15 lbs / 68 g
Warning: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Usage
How to Take It
01
2 Capsules Daily in the Morning
Take 2 capsules every morning with food. NAD+ precursors align best with the body's circadian NAD+ rhythm when taken in the morning. Fat-soluble compounds in the formula absorb better with a meal.
02
Take with Food
This formula contains fat-soluble compounds that absorb most effectively with a meal containing healthy fats. A breakfast with avocado, eggs, or olive oil supports peak absorption across all three ingredients.
03
Stay Consistent for 8–12 Weeks
Benefits for energy, cognitive clarity and cellular health build progressively over 8–12 weeks of consistent supplementation. NAD+ restoration and sirtuin activation are cumulative — give your body the time it needs.
Swipe through the day →
Best taken in the morning with food. The combination of NAD+, quercetin, and resveratrol works synergistically — all three compounds should be taken together daily for compound anti-ageing effects.
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Your routine
Why Subscribe?
Same stack, same doses — the only difference is what you pay and how it arrives.
Save 20% + Free Express Shipping
Lock in 20% off every order with free express shipping delivered to your door. No reordering, no running out — it just arrives.
Real Results Take Time
Longevity+ works through accumulation. NAD+ restoration, senolytic clearance, and sirtuin activation all build progressively over 8–12 weeks. Give your body the time the science actually requires.
Full Flexibility, Zero Lock-In
Swap products, skip a month, or cancel any time. Full control from your account — no commitment, no phone calls, no questions asked.
Best Value
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Delivery
Shipping
Dispatched Within 1 Business Day
Every order is packed and dispatched the same or next business day. No sitting in a warehouse.
2–4 Business Days Express
All orders ship via express delivery. Standard timeframe is 2–4 business days from dispatch to your door.
Free Shipping for Subscribers
Subscribe & Save customers get free express shipping on every order — automatically applied, no minimum spend, no codes required.
US Shipping Only
We currently ship within the United States only. A flat express shipping rate applies to all one-time orders at checkout.
Delivery estimates begin from the date of dispatch. Business days exclude weekends and public holidays.
Verified Customer Reviews
What our customers say.
4.8
13 verified reviews
I've been following the longevity science for years and this formula is impressively well-researched. The 98% resveratrol standardisation and the quercetin as a CD38 inhibitor alongside the NAD+ shows someone actually read the literature before formulating.
The quercetin as a senolytic alongside the NAD+ is an important combination most longevity products miss. Every ingredient choice here shows real understanding of the science. Energy and vitality are both noticeably better.
Good product and comprehensive formula. Longevity supplements work on a long time horizon — I'm judging this on a three-month window and the improvements to energy and sleep quality are clear and consistent.
Eight weeks in and sleep quality, morning energy, and general resilience have all improved. The kind of product that makes a difference over years — I'm committed to this for the long run.
Stacked this with NMN and the synergy is obvious. Sustained energy, faster recovery, sharper focus. The combination of NAD+ and sirtuin activation makes physiological sense.
At my age — mid-sixties — energy and vitality have become priorities. This is the most research-backed longevity formula I've found and after three months the difference is real and measurable.
Really excellent value for the quality of ingredients included. Nothing underdosed, no fillers, and every compound has a clear research rationale. A daily essential I won't be dropping.
Showing 8 of 13 reviews